This course provides essential information for patients and families dealing with Generalized Pustular Psoriasis (GPP), a severe and rare form of psoriatic disease. It explains GPP’s clinical presentation, characterized by widespread sterile pustules, pain, and potential complications like respiratory distress and heart failure. The course highlights the importance of urgent medical treatment, including hospitalization, systemic medications, and nursing care with wet and dry wraps. Emotional challenges, such as anxiety and social stigma, are addressed, alongside long-term management strategies, including the gradual weaning of steroids and identifying triggers to prevent flares. The course empowers patients through personalized care plans, education on managing flare-ups, and fostering health literacy.